A cell is the basic unit of life. Cells contain DNA, a molecule that stores the instructions that cells use to produce the more than 100,000 different types of proteins that make up the human body. DNA is damaged by exposure to radiation, chemicals, and natural metabolism as we age. Scroll down to learn how Eterna’s cell engineering platform addresses all areas of cellular dysfunction.

Synthetic mRNA

Messenger RNA (mRNA) carries the instructions contained in DNA to the cellular machinery that translates these instructions into functional proteins. Eterna makes mRNA with various chemical and structural enhancements (e.g., immuno-stealthing modifications, circular formats, etc.), and uses these molecules to improve cell function.

ToRNAdo™ mRNA Delivery

Eterna formulates mRNA using lipid nanoparticle (LNP) technology. The ToRNAdo™ delivery system surrounds and protects the mRNA cargo, enabling efficient delivery into human cells.

mRNA Gene Editing

Eterna uses mRNA to express gene editing proteins. These proteins are capable of deactivating, repairing, inserting, or replacing specific DNA sequences in living cells to repair genetic damage and confer new functionality to cells.

mRNA Cell Reprogramming

Eterna uses mRNA to express reprogramming proteins. These proteins re-write a cell’s gene expression program, enabling a somatic cell, such as a skin cell, to transform into another type of cell, such as a neuron or a stem cell. In one application of this technology, Eterna makes induced pluripotent stem (iPS) cells, a cell type that can differentiate into any needed cell.